Synthesis of Polyfunctionalized Pyrroles from Furfurylamines and Ynones via CuCl₂-Catalyzed and Iodine-Mediated Oxidative Annulation of N-Furfuryl-β-Enaminones

Abstract

The copper chloride catalyzed and iodine-mediated oxidative annulation of N-furfuryl-β-enaminones, generated in situ from reactions of furfurylamines with ynones, provides a practical access to polyfunctionalized pyrroles under mild conditions. This protocol expands the synthetic application of furans, which are readily available and can be sustainably sourced.

Key words

annulation - N-furfuryl-β-enaminones - furans - pyrroles - sustainable chemistry

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